JM6 ID:1644
Synonyms: |
CAS NO : 1008119-83-2 |
|
Molecular Formula: C23H26N4O6S2 |
Molecular Weight: 518.6 |
Purity: 98% |
Solubility: In DMSO |
Storage: -20°C |
Availability and Price
|
If the item is temporarily out of stock. Please email to sales@betterbiochem.com,we will inform you when we have it in stock. |
In Stock |
|
Order |
Remarks:JM6 is a prodrug inhibitor of kynurenine 3-monooxygenase (KMO) that increases kynurenic acid levels and reduces extracellular glutamate in the brain. Metabolites in the kynurenine pathway, generated by tryptophan degradation, are thought to play an important role in neurodegenerative disorders, including Alzheimer's and Huntington's diseases. Chronic oral administration of JM6 inhibits KMO in the blood, increasing kynurenic acid levels and reducing extracellular glutamate in the brain. JM6 prevents spatial memory deficits, anxiety-related behavior, and synaptic loss. JM6 also extends life span, prevents synaptic loss, and decreases microglial activation in a mouse model of Huntington's disease.
Quality Control
H-NMR,C-NMR,LC-MS,HPLC. |
|
Related Products
Others
|